Equine Pituitary Pars Intermedia Dysfunction (PPID)

Pituitary pars intermedia dysfunction (PPID), also known as Equine Cushing's Disease, is a common endocrine disorder that affects oler equids. It is a slowly progressive degenerative disease of the hypothalamic dopaminergic neurons. Loss of dopaminergic neurons inhibits control of the pars intermedia melanotropes and gives rise to formation of hyperplasia and adenomas in the pars intermedia. What this means is that the hypothalamus and pituitary gland fail to communicate properly. This leads to hyperactivity of the pituitary gland and over

PPID is an uncurable condition that can be managed through medication, diet, and exercise. The main challenge for a horse with PPID is to manage and prevent recurrent bouts of laminitis, hoof abscesses, and infection. With proper diet and exercise management, careful monitoring, regular testing, a horse with PPID can live a long, comfortable life.


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